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management causes chronic cll differential lymphocytic mds myelodysplastic anemia blood diffuse hemeonc lad lymphadenopathy myelodysplasia product reactions syndrome syndromes transfusions
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Causes of Thrombocytopenia ... Megakaryopoiesis • Aplastic ... Leukemia, Tumour ... Vasculitis • Infection ... #Hematology
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
- Differential Diagnosis ... Algorithm Reactive ... History of Bleeding, Infection ... #Algorithm #Causes ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... risk-stratification • Risks: infection ... transformation to acute leukemia ... Management #treatment #hematology ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
pain, bleeding, infections ... Neutrophils • Immature/Myeloblasts ... infiltrates (anemia, thrombocytopenia ... #Hematology #Oncology ... #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
/fevers • Thrombocytopenia ... Idiopathic • Infections ... virus (EBV) • Leukemia ... #Anemia #oncology ... #hematology #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
adults in the west ... Neutropenia, anemia, thrombocytopenia ... Pure red cell aplasia ... #diagnosis #workup ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
minimal tumor burden Diagnosis ... Complications: 1) Infection ... with anemia or thrombocytopenia ... #oncology #hematology ... #hemeonc #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Causes • Anemia • Aplastic ... Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
indirect Coombs test ... purpura & severe thrombocytopenia ... due to marrow aplasia ... #Transfusions #diagnosis ... #management #hematology
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