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diagnosis causes management mds algorithm apml atlas cancer chronic dermatology differentiation effusions eosinophilia erythematosus gap globulin key knee lupus lymphocytic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
APML, CLL Acute ... ALL (Acute Lymphoblastic ... Neutrophils • Immature/Myeloblasts ... • Tumor lysis syndrome ... #Hematology #Oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... transformation to acute ... leukemia Management ... Management #treatment #hematology ... #oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... Chronic myeloid leukemia ... Diagnosis #Causes #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Richter’s Syndrome ... ’s lymphoma or acute ... syndrome • Smoldering ... diagnosis #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic ... Chronic Myelogenous Leukemia ... Cell Leukemia ... blood count with differential ... #hematology #oncology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Eosinophilia - Differential ... Primary: - CML ... Mastocytosis - Acute ... Hypereosinophilic Syndrome ... Diagnosis #Causes #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Liver diseases, Myelodysplastic ... syndrome, Increased ... Malignant tumors, Acute ... key #diagnosis #differential ... #hematology
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Acute febrile ... general feeling of ill ... , breast CA - Hematologic ... - Lupus - Leukemia ... #oncology
Causes of Knee Effusions - Differential Diagnosis Framework Knee Effusion Red Flags: 1. Fever/Chills/Joint pain/Night sweats/Weight loss - DDX: -
Knee Effusions - Differential ... Seronegative Reactive Syndrome ... - Acute rheumatic ... Effusions: - Hematologic ... - Leukemia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Induce blast cell ... initiation • Differential ... diagnosis #management #hematology ... #oncology
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