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oncology pathophysiology syndrome algorithm apml arterial bandemia causes classification coagulation dic differentiation disseminated dress embolism essential et hodgkins lymphoma microangiopathy
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... Initial labs: CBC ... hemoglobin/hemosiderin, Hepatic ... #Diagnosis #Management ... #Algorithm #hematology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... hypotension or septic ... #Bandemia #differential ... #WBC #CBC #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... hydration • RBC ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... reflection of intravascular ... from ischemia WBC ... count and differential ... #Workup #Hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Diagnosis Framework ... considered in all cases ... Hyperhomocysteinemia - Heparin-induced ... - Disseminated intravascular ... pathophysiology #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... if high risk if WBC ... initiation • Differential ... Renal Failure Treatment ... #management #hematology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Definition: • Severe adverse drug reaction, characterized by
Edema in 70% of cases ... Resolution > 15 days Differentials ... disease: symptomatic treatment ... DRESS #Syndrome #dermatology ... #diagnosis #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... classification #hematology ... #oncology #management
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... : On the CBC, ... Thrombocythemia #ET #hematology ... #diagnosis #management ... #hematology
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