13 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... Neutrophils • Immature/Myeloblasts ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
peripheral blood leukocytes ... on the left Myeloblast ... neutrophil #WBC #CBC #hematology
Oncologic Emergencies - Differential Diagnosis Framework

HEMATOLOGIC ONCOLOGIC EMERGENCIES:
Hyperviscosity Syndrome:
 • Spontaneous bleeding
 • Shortness of breath
Diagnosis Framework HEMATOLOGIC ... Hyperviscosity Syndrome ... Superior Vena Cava Syndrome ... : Tumor Lysis Syndrome ... Vomiting, decreased urine
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis)
Major criteria 
 1. Abrupt onset of tender
Criteria for Sweet Syndrome ... an underlying hematologic ... C-reactive protein; leukocyte ... neutrophils #Sweet #Syndrome ... Criteria #Diagnosis #Hematology
Causes of Ascites
Normal Peritoneum
Portal hypertension (SAAG > 1.1 g/dL)
  1. Hepatic congestionl
- Budd-Chiari syndrome ... - Nephrotic syndrome ... Nephrogenic ascites - Urine ... #differential #hepatology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
BUN - Decreased urine ... the hepatorenal syndrome ... LiverFailure #Hepatic #Hepatology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
Product Types: • Leukocyte ... flank pain, dark urine ... proteins on plts, leukocytes ... diagnosis #management #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... passage of red-brown urine ... hemolytic #anemia #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... lymphoma • Evans' syndrome ... Shrinking lung syndrome ... edema, active urine ... vein thrombosis Hematologic
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
• Metabolic syndrome ... Intracellular (leukocyte ... Gout #Comparison #rheumatology