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diagnosis management differential hematology nephrology oncology blood causes clinical infectiousdiseases acute algorithm dermatology disease fever lysis microbiology product reactions renal
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
• Blasts > 10% leukocytes ... Neutrophils • Immature/Myeloblasts ... develop leukostasis syndrome ... AML Dx: • ↑ Leukocyte ... • Tumor lysis syndrome
“Step by Step” – the new kid on the block – aims to risk stratify this
investigations and treatments ... >21 days - No leukocytes ... in urine - Procalcitonin ... Pediatrics #Peds #Febrile
Hantavirus Pathogen: Hantavirus - Rodents are the primary reservoir Transmission: • Shed in the urine, feces, saliva of
• Shed in the urine ... Cardiopulmonary Syndrome ... (HCPS): Febrile ... • Autopsy PCR Treatment ... diagnosis #management #treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... organ damage • Treatment ... : - If febrile ... Low calcium • Treatment ... - Hyperkalemia treatment
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... oxidative iniury Treatment ... hour with goal urine ... Summary #causes #treatment
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Compartment syndrome ... Weakness - Dark urine ... or compartment syndrome ... Treatment of underlying ... hour with goal urine
Hematuria in Post-Renal Transplant Patient Prevalence up to 12% in the postrenal transplant patient • Bacterial: Escherichia
(Goodpasture's syndrome ... kidney #blood #urine ... #management #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Rare: DAH, acute febrile ... Renal Failure Treatment ... Differentiation #Syndrome
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Criteria for Sweet Syndrome ... (Acute Febrile ... Excellent response to treatment ... C-reactive protein; leukocyte ... #Acute #Febrile
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... uric acid, LDH, Urine ... of the above Treatment ... #Tumor #Lysis #Syndrome
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