12 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
#purpura #TTP # ... HemolyticUremicSyndrome ... #HUS #thrombocytopenia ... #Comparison #Diagnosis ... #Table #Hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
for workup of thrombocytopenia ... TTP/HUS indicates ... thrombotic thrombocytopenic ... purpura/hemolytic ... , Hematology 2012
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
• Thrombotic Thrombocytopenic ... Purpura (TTP) ... Toxin-Mediated HUS ... HUS (aHUS) ... Microangiopathy #TMA #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
inflammation • Thrombocytopenia ... Primary Causes: - Thrombocytopenia ... disease - DIC/TTP/HUS ... : • DIC, TTP/HUS ... #nonpalpable #dermatology
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
of Thrombotic Thrombocytopenic ... Purpura (TTP) ... HUS), Serum creatinine ... HUS) Treatment ... #rheumatology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Petechiae • Purpura ... Hemorrhagic bullae • Purpura ... DDX: • TMA’s (HUS ... - MAHA: TTP/HUS ... treatment #management #hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Thrombocytopenia ... Pregnancy - TTP/HUS ... Bloodman #Pregnancy #Thrombocytopenia ... AFLP #obstetrics #hematology ... diagnosis #table #comparison
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
microangiopathy: Thrombotic thrombocytopenic ... purpura (TTP), ... uremic syndrome (HUS ... differential #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
Lymphocytes - T or B lineage ... ALL is of B-cell lineage ... Neutrophils • Immature/Myeloblasts ... infiltrates (anemia, thrombocytopenia ... #Leukemia #Hematology
Primary Dermatological Lesions
Primary lesions are physical changes in the skin considered to be caused directly by
BURROW: burrows are linear ... PETECHIAE and PURPURA ... Purpura are larger ... lesions that contain pus ... #Diagnosis #Dermatology