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diagnosis management differential oncology algorithm anemia systemic disorders elevatedmcv generalized hepatology hepatopulmonary intravascular leukemia macrocytosis pruritus rheumatology secondary syndromes workup
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Myelodysplastic Syndromes ... Cells, Normal WBCs ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... plateletcount), peripheral blood ... function test, ANA (e.g ... or if a primary hematologic ... #Workup #hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Iron Deficiency (Eg ... Causes: Chronic ... Blood Loss, Occult ... #Hematology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
blasts and high WBC ... count cause hyperviscosity ... • Lab values: WBC ... unless worrisome EKG ... diagnosis #management #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... Hemolytic uremic syndrome ... • Intrinsic RBC ... differential #diagnosis #hematology
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Treatment Stop offending agents: • List as allergies
Symptoms (DRESS) Syndrome ... Treatment Stop ... Methylprednisolone 0.5 - 1.5 mg/kg ... monitoring: • CBC ... #dermatology
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
for Irradiated RBC ... Transfusions: Cellular blood ... disorders (DiGeorge Syndrome ... HLA-selected products (e.g ... #Indications #Hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Systemic and Primary Causes ... / Systemic == Blood ... Hyperthyroidism CBC ... Myelodisplastic syndrome ... #generalized #dermatology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
• Peripheral blood ... for secondary causes ... glucocorticoid treatment ... signs or symptoms (eg ... Differential #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if high risk if WBC ... Prednisone 5mg/kg ... diagnosis #management #hematology
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