11 results
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - ... Platelet Count ... Reactive: • Anemia ... Myelofibrosis • Chronic Myeloid ... #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... MF) • Chronic myeloid
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
- Markers and Differential ... Pelger-Huet, Macrocytic anemia ... - Amy Chung, MD ... #hematology #Markers ... #Differential #
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Elevated Platelet ... Count - Differential ... blood loss, Acute hemolysis ... , deficiency anemia ... #Platelets #Differential
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Liver Disease, MDS ... Unstable hemoglobin disorders ... lymphoma, Multiple myeloma ... RBC #Morphology #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... with or without platelet ... Consider RBC membrane disorder ... #Anemia #Differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly ... Vasculopathy #Purpura #Differential ... #nonpalpable #dermatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... significance (MGUS), CLL, Myeloma ... #anemia #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
Disorders - Differential ... Infection exposure (l MD ... changes), high MCV anemia ... #Disorders #Differential ... Causes #Workup #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... , or all three myeloid ... Disorders • Nutritional ... blood count with differential ... Syndromes #diagnosis #hematology