14 results
Anemia - Workup and Differential Diagnosis
 - History, Physical Exam, Labs
 - Microcytic
 - Normocytic
 -
Anemia - Workup ... - Normocytic ... Hemolytic #Anemia ... #Workup #Differential ... #Diagnosis #causes
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... by MCV Microcytic ... Normocytic ( ... Non-megaloblastic: Liver disease ... #Diagnosis #hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... , Multiple myeloma ... , Multiple myeloma ... RBC #Morphology #differential ... #diagnosis #hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
MCV - <80fL - "Microcytic ... 80 - 96 fL - "Normocytic ... morphologic #mcv #differential ... #diagnosis #causes ... #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Normal Blood Smear
 •
Causes of Anemia ... Formation • Multiple Myeloma ... #Macrocytic ... #elevatedMCV #Differential ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... e.g. lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... younger pts) Differential ... significance (MGUS), CLL, Myeloma ... #hemolytic #anemia ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
for workup, including ... blood loss, Acute hemolysis ... , deficiency anemia ... Metastatic cancer, Lymphoma ... Vasculitides, IBD, Celiac disease
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... result in severe anemia ... anemia Indirect ... WBC count and differential ... #Workup #Hematology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... Workup: • Full ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #hematology #oncology