29 results
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
Hyperviscosity Syndrome ... - Causes and Treatment ... Hyperviscosity #Syndrome ... #Causes #Differential ... #Management
Classification of Jaundice
Unconjugated hyperbilirubinemia (predominantly indirect bilirubin)
 • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
hyperbilirubinemia, Gilbert syndrome ... Crigler-Najjar syndrome ... Hereditary Cholestatic Syndromes ... Dubin-Johnson syndrome ... , Rotor syndrome
Priapism 

Secondary Causes:
Medications- intracavernosal injections, anticoagulants, PDE5 inhibitors, alpha blockers, methylphenidate, cocaine
Any hyperviscosity syndrome (SCD, leukemia,
Secondary Causes ... intracavernosal injections ... hyperviscosity syndrome ... Priapism #Diagnosis #Management ... #Urology #Differential
Causes of Splenic Infarcts - Differential Diagnosis
 • Myeloid disorders: Myeloproliferative neoplasms (myelofibrosis, polycythemia vera, essential
Causes of Splenic ... Infarcts - Differential ... Diagnosis • Myeloid ... Myelodysplastic syndromes ... Antiphospholipid syndrome
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
Causes of Thrombocytosis ... - Differential ... Thrombocytosis): • Acute infection ... Myelodysplastic syndrome ... MF) • Chronic myeloid
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
CML (Chronic Myeloid ... • Neutrophils (myeloid ... (Acute Myeloid ... develop leukostasis syndrome ... • Tumor lysis syndrome
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Imaging: CXR- pulmonary ... Diagnosis: Infection ... Differentiation #Syndrome ... #management #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Summary myelo ... old, ~10,000 new cases ... risk-stratification • Risks: infection ... Myelodysplastic #Syndrome
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... Myelodysplastic syndromes ... , or all three myeloid ... (CML) • Felty Syndrome ... blood count with differential
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
leak syndrome ... edema, compartment syndrome ... of infections) ... #leak #syndrome ... #diagnosis #management