6 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Monoclonal Gammopathy ... Diagnosis Neurologic-Centered ... Ig deposition disease ... #Gammopathy #Clinical ... Differential #Diagnosis #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
whom there are no clinical ... concerning for myeloma ... #monoclonal #gammopathy ... algorithm #diagnosis #management ... #hematology #multiplemyeloma
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... angioedema • vWD • acquired ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Gammopathy of Undetermined ... Significance (MGUS ... rituximab (in clinical ... #Monoclonal #Gammopathy ... Complications #diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... significance (MGUS ... ), CLL, Myeloma ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
: • MGUS • Multiple ... myeloma • Waldenstrom ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology