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diagnosis clinical monoclonal differential gammopathy oncology microscopy smear formation algorithm anemia multiplemyeloma protein significance agglutinin aml atlas autoinflammatory biopsy blood
Rouleaux formation is common in IgM gammopathy and may be particularly striking Genevieve Crane, MD, PhD@evemariecrane #Rouleaux #formation
Rouleaux formation ... evemariecrane #Rouleaux ... IgM #gammopathy #MGUS ... #Clinical #Pathology ... #Hematology #Smear
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
with extensive rouleaux ... other forms of myeloma ... PlasmaCell #leukemia #rouleaux ... Clinical #Smear #Hematology ... #Pathology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... 1.5 gm/dL) IgM MGUS ... , low-risk MGUS ... concerning for myeloma ... diagnosis #management #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Significance (MGUS ... Features: POEMS, AL amyloid ... deposits: Ig-related amyloid ... #Significance #MGUS ... Differential #Diagnosis #hematology
Hypersegmented neutrophil in a case of acute myeloid leukemia. Dysplastic neutrophils are typically hypolobated but can be
case of acute myeloid ... AML #Clinical #Hematology ... #Pathology #Smear
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... sub-types based on the hematologic ... to IgM multiple myeloma ... to light-chain myeloma ... #Significance #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
vasculitis • Hematologic ... criteria for 1) hematologic ... conditions - multiple myeloma ... peripheral blood myeloid ... cells NEJM Review
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• MM • WM • MGUS ... • MGCS • MGRS ... POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... Paraproteinemias #Hematology
Eyelid Melanoma - Despite conservative interventions, the stye had persisted and the skin had become noticeably
Eyelid Melanoma ... the left upper eyelid ... C) #Clinical #Pathology ... #Derm #Eyelid # ... Melanoma #Microscopy #NEJM
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
Suspected multiple myeloma ... which multiple myeloma ... bleeding) • Rouleaux ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology
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