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diagnosis differential rheumatology treatment oncology algorithm dermatology hepatology causes clinical liver monoclonal myelodysplastic table anemia erythematosus fingernail gastroenterology hepatitis immunology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... criteria for 1) hematologic ... peripheral blood myeloid ... cells NEJM Review
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Aggressive disease ... other forms of myeloma ... Clinical #Smear #Hematology ... #Pathology
End Stage Liver Disease (Cirrhosis) - Complications • Ascites • Esophageal Varices • Hepatic
End Stage Liver Disease ... Hepatopulmonary Syndrome ... • Hepatorenal Syndrom ... Complications #diagnosis #management ... #summary #hepatology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... lymphoma, multiple myeloma ... thrombocythemia), Autoimmune disease ... #treatment #hematology
Castleman's Disease and Associated Syndromes HYALINE VASCULAR VARIANT • unicentric, HHV8-ve, children and young. • Hyalinized vessels
Castleman's Disease ... and Associated Syndromes ... Pathogenesis "IL6 syndrome ... cell disorders (myeloma ... Variants #Diagnosis #Pathology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... • Myeloid hemopathy ... appearing during the disease ... myelodysplastic #syndrome ... differential #diagnosis #dermatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
lymphoma, melanoma, myeloma ... Metabolic: Wilson Disease ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... Diagnosis #causes #hepatology
Nail Findings & Associated Conditions Change in color, texture, or shape can be harmless, but may suggest
underlying systemic disease ... • Green Nail Syndrome ... • Yellow Nail Syndrome ... Nail #fingernail #pathology ... differential #diagnosis #dermatology
Nail Findings & Associated Conditions Change in color, texture, or shape can be harmless, but may suggest
underlying systemic disease ... • Green Nail Syndrome ... • Yellow Nail Syndrome ... Nail #fingernail #pathology ... differential #diagnosis #dermatology
Hypocalcemia - Diagnosis and Management PTH Independent (↑ PTH) • LOW VIT D -
Diagnosis and Management ... Activation: Liver disease ... , Kidney Disease ... Infiltrative: Amyloid ... - DiGeorge Syndrome
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