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diagnosis management differential algorithm causes leukemia monoclonal workup arthritis chronic hemolytic lymphocytic mds mgus rheumatoid agglutinin aplastic atlas autoinflammatory blood
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... Abnormalities: macrocytic anemia ... (12%) • giant cell ... cells NEJM Review ... Autoinflammatory #Somatic #rheumatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic ... Summary myelo ... cytopenias (usually anemia ... Management #treatment #hematology ... #oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Disorders - Markers and ... Disorders - Myelodysplastic ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... Blood #Disorders #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... three myeloid hematopoiesis ... • Aplastic Anemia ... Myeloproliferative Disease ... #hematology #oncology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... vera (PV) • Myelodysplastic ... syndrome • Myelofibrosis ... MF) • Chronic myeloid ... Diagnosis #Causes #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... , Myelodysplastic ... syndrome, Increased ... Hemolytic uremic syndrome ... #differential #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Formation • Multiple Myeloma ... Dysplastic • Myelodysplastic ... Syndromes Macrocytosis ... • Rule out B12 and ... Algorithm #Causes #Hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... 40 ml/min A - Anemia ... diseases, CML, ... MGUS #diagnosis #hematology ... #oncology
Multiple Myeloma Diagnosis and Management Summary Clinical Signs: • hyperCalcemia 28% (bone demineralization) • Renal disease 48%
Multiple Myeloma ... demineralization) • Renal disease ... pathologic fx) ... plasma clonal cell ... Diagnosis #Management #oncology
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