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diagnosis management algorithm leukemia monoclonal anemia causes dermatology hodgkins lymphoma mgus myelodysplastic workup acquired agglutinin ana antibodies antinuclear atrophy autoinflammatory
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... thromboembolic disease ... cells NEJM Review ... Autoinflammatory #Somatic #rheumatology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
• Myeloid hemopathy ... appearing during the disease ... #differential # ... diagnosis #dermatology ... #oncology #clinical
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... capillary leak syndrome ... Ig deposition disease ... #Diagnosis #hematology ... #oncology
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Aggressive disease ... other forms of myeloma ... rouleaux #formation #Clinical ... #Smear #Hematology ... #Pathology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
Lymphadenopathy - Differential ... • Kikuchi Disease ... Epitrochlear (Always pathologic ... Algorithm #Causes #Hematology ... #Oncology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
Multiple Myeloma ... ULN R - Renal disease ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology ... #oncology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... lymphoma, multiple myeloma ... thrombocythemia), Autoimmune disease ... Management #treatment #hematology ... #differential
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Volume (MCV) - Differential ... Formation • Multiple Myeloma ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
• Clinical features ... involvement Differential ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... POEMS (Sclerotic myeloma ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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