47 results
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
thromboembolic disease ... vasculitis • Hematologic ... criteria for 1) hematologic ... peripheral blood myeloid ... cells NEJM Review
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Aggressive disease ... other forms of myeloma ... Clinical #Smear #Hematology ... #Pathology
Parinaud's Syndrome
What?
 - Impaired upgaze
 - Light-near dissociation
 - Convergence retraction nystagmus
 - Eyelid retraction (Collier's
Parinaud's Syndrome ... retraction nystagmus - Eyelid ... retraction (Collier's sign ... → "setting sun sign ... " - Vascular disease
Castleman's Disease and Associated Syndromes
HYALINE VASCULAR VARIANT
 • unicentric, HHV8-ve, children and young.
 • Hyalinized vessels
Castleman's Disease ... and Associated Syndromes ... Pathogenesis "IL6 syndrome ... cell disorders (myeloma ... Variants #Diagnosis #Pathology
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... • Myeloid hemopathy ... appearing during the disease ... myelodysplastic #syndrome ... differential #diagnosis #dermatology
Rheumatoid Arthritis Summary
MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Tunnel, Sicca Syndrome ... Scleritis, Heart Disease ... Nodules, Pulmonary Disease ... RA #diagnosis #rheumatology ... #signs #symptoms
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
lymphoma, melanoma, myeloma ... Metabolic: Wilson Disease ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... Diagnosis #causes #hepatology
Parinaud's syndrome
What?
 • Light-near dissociation (tectal pupils)
 • Convergence retraction nystagmus
 • Eyelid retraction (Collier's sign)
Parinaud's syndrome ... retraction nystagmus • Eyelid ... retraction (Collier's sign ... "setting sun" sign ... • Vascular disease
Nail Findings & Associated Conditions
Change in color, texture, or shape can be harmless, but may suggest
underlying systemic disease ... • Green Nail Syndrome ... • Yellow Nail Syndrome ... Nail #fingernail #pathology ... differential #diagnosis #dermatology
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... Summary Clinical Signs ... demineralization) • Renal disease ... osteolytic lesions and pathologic ... #Multiple #Myeloma