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diagnosis rheumatology algorithm dermatology management causes hepatology oncology neurology symptoms liver vasculitis workup hepatitis nail abnormal anemia arthritis classification cutaneous
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Clinical Syndrome ... : • Common Clinical ... thromboembolic disease ... vasculitis • Hematologic ... cells NEJM Review
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
• Myeloid hemopathy ... appearing during the disease ... #differential # ... diagnosis #dermatology ... #oncology #clinical
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Aggressive disease ... other forms of myeloma ... rouleaux #formation #Clinical ... #Smear #Hematology ... #Pathology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Transaminitis - Differential ... lymphoma, melanoma, myeloma ... Metabolic: Wilson Disease ... Vascular: Budd-chiari syndrome ... Diagnosis #causes #hepatology
Nail Findings & Associated Conditions Change in color, texture, or shape can be harmless, but may suggest
underlying systemic disease ... • Yellow Nail Syndrome ... Nail #fingernail #pathology ... #differential # ... diagnosis #dermatology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... capillary leak syndrome ... • Schnitzler syndrome ... Ig deposition disease ... #Diagnosis #hematology
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Hepatomegaly - Differential ... Polycythemia • Multiple Myeloma ... Hemochromatosis • Wilson's Disease ... • Budd-Chiari Syndrome ... Algorithm #Causes #Hepatology
Nail Findings & Associated Conditions Change in color, texture, or shape can be harmless, but may suggest
underlying systemic disease ... • Yellow Nail Syndrome ... Nail #fingernail #pathology ... #differential # ... diagnosis #dermatology
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Origin (FUO) - Differential ... Lemierre's syndrome ... Malignancy: - Hematologic ... Leukemia, Multiple myeloma ... #Origin #FUO #Differential
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... lymphoma, multiple myeloma ... thrombocythemia), Autoimmune disease ... Management #treatment #hematology ... #differential
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