10 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
(MGUS) - Differential ... capillary leak syndrome ... • Schnitzler syndrome ... Diagnosis #hematology ... #oncology
Cutaneous manifestations associated with myelodysplastic syndrome
 • Myeloid hemopathy with the most frequent skin lesions (20%)
syndromeMyeloid ... dermatosis: Sweet's syndrome ... #syndrome #differential ... #diagnosis #dermatology ... #oncology #clinical
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... Hyperviscosity syndrome ... (Dermato-neuro syndrome ... #Monoclonal #Differential ... #Diagnosis #Oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... 40 ml/min A - Anemia ... plasmacytoma, POEMs syndrome ... #diagnosis #hematology ... #oncology
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Hematologic ... sinusoidal obstructive syndrome ... Capillary leak syndrome ... • Tumor lysis syndrome ... #Differential #
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
, or all three myeloid ... Myeloproliferative Disease ... blood count with differential ... #Syndromes #diagnosis ... #hematology #oncology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis Monoclonal ... significance (MGUS ... ), CLL, Myeloma ... #hematology #diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Gammopathy Include: • MGUS ... changes (POEMS syndrome ... Thalassemia, Sickle cell anemia ... Gap #ProteinGap #differential ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... #workup #oncology ... #hematology
Myelodysplastic syndromes current treatment algorithm 2018.

From Blood Cancer Journal, Published 24 May 2018

Myelodysplastic syndromes (MDS) are
syndromes current ... syndromes (MDS) ... clonal evolution to acute ... myeloid leukemia ... tolerate anemia