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Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Transverse Myelitis - Clinical ... the spinal cord (Myelopathy ... Weakness: - Weakness ... diagnosis #management #neurology
Neurological Patterns of Weakness • Hemispheric lesion • Brainstem lesion • Spinal cord lesion • Polyneuropathy
Neurological Patterns of Weakness ... Polyneuropathy • Myopathy ... #Neurology #Patterns ... #Weakness #diagnosis
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy • Central or peripheral neurologic disease
Proximal Muscle Weakness ... Mimic Inflammatory Myopathy ... or peripheral neurologic ... Mitochondrial myopathy ... differential #causes #neurology
Causes of Peripheral Weakness - With and Without Sensory Changes - Differential Diagnosis Algorithm With Sensory Changes:
of Peripheral Weakness ... • No Objective Weakness ... Oculomotor • Myopathy ... #Peripheral #Weakness ... #Sensory #Neurology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
80%) - Proximal Weakness ... 10%) - Proximal Weakness ... femoral heads • Myopathy ... Complications #pathophysiology
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Generalized Weakness ... I am weak": • Myopathy ... Rhabdomyolysis, Critical ... #Generalized #Weakness ... Diagnosis #causes #neurology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm No Objective Weakness • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... • Congenital Myopathy ... #Peripheral #Weakness ... #Neurology #Differential
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... heavy metals), Critical ... Mitochondrial myopathy ... Neuromuscular #Weakness ... differential #diagnosis #neurology
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Elevation (Pain > Weakness ... immobility • Critical ... Illness Myopathy ... Chronic Causes (Weakness ... PROXIMAL MUSCLE WEAKNESS
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Myopathy: ... mediated necrotizing myopathy ... aminotransferases • Serology ... Differential #Diagnosis #neurology
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