156 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... proximal myalgia and weakness ... symmetric muscle weakness ... Guillain-Barré syndrome ... IU/I • SAMS clinical
Hypothyroidism – symptoms and signs.

Symptoms: 
Tiredness/malaise, 
Weight gain,
Anorexia,
Cold intolerance, 
Poor memory,
Change in appearance, 
Depression, 
Poor libido,
Myalgia, Muscle weakness ... Psychosis, Deafness ... of movement, Deafness ... Carpal timel syndrome ... hypertrophy, Proximal myopathy
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Guillain-Barre syndrome ... heavy metals), Critical ... Lambert Eaton Syndrome ... Mitochondrial myopathy
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... level of muscle weakness ... anti-synthetase syndrome ... and anti-HMGCR myopathy ... have significant weakness
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
80%) - Proximal Weakness ... 10%) - Proximal Weakness ... femoral heads • Myopathy ... Complications #pathophysiology
Kounis Syndrome (Allergic Angina) - Pathophysiology

#Kounis #Syndrome #Allergic #Angina #Pathophysiology #cardiology
Kounis Syndrome ... Allergic Angina) - Pathophysiology ... #Kounis #Syndrome ... Allergic #Angina #Pathophysiology ... #cardiology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
of Peripheral Weakness ... No Objective Weakness ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... #Peripheral #Weakness
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... Lambert-Eaton - Isaacs' syndrome ... Myopathy: ... mediated necrotizing myopathy
Acute Spinal Cord Injuries: Pathogenesis and clinical findings
 • Anterior Cord Syndrome -> Anterior spinal artery
Pathogenesis and clinical ... Anterior Cord Syndrome ... Upper extremity weakness ... anesthesia. leg weakness ... #diagnosis #pathophysiology
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Elevation (Pain > Weakness ... immobility • Critical ... Illness Myopathy ... Chronic Causes (Weakness ... PROXIMAL MUSCLE WEAKNESS