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diagnosis clinical differential management algorithm pocus causes ultrasound cardiology treatment peds infectiousdiseases pediatrics signs rheumatology symptoms pulmonary comparison microbiology dermatology
CARDIAC MYOCYTE POTENTIALS #Pathophysiology #Cardiology #Cardiac #Myocyte #Ventricular #ActionPotentials #Channels #Phases
CARDIAC MYOCYTE ... Cardiology #Cardiac #Myocyte
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Cardiac: • Myocyte ... myocarditis, rheumatic fever
Cardiac Myocyte Contractile cycle - Ca2+ binds to TnC → TnI is inhibited → conformational change
Cardiac Myocyte ... Pathophysiology #Cardiology #Myocyte
Action potential in cardiomyocytes The action potential in typical cardiomyocytes is composed of 5 phases (0-4), beginning
ActionPotential #Myocytes
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Overlap Syndrome: Fever ... ANTI-SYNTHETASE SYNDROME: • Fever ... levels 50X ULN • Myocyte
Cardiomyopathies Manifestations of cardiomyopathy (CM) range from microscopic alterations in cardiac myocytes to fulminant Heart Failure
alterations in cardiac myocytes
Faget Sign - Pulse-Temperature Dissociation Causes of Relative Bradycardia • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... Intermittent Fever ... or no fever •
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Fever - Pyrogen ... (neutrophils, monocytes ... production → Fever ... #Fever #Pathophysiology
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
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