43 results
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Motor Nerves: ALS ... Guillain-Barre syndrome ... Mitochondrial myopathy ... #differential #diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... heliotrope rash, Shaw sign ... , holster sign, ... anti-synthetase syndrome ... and anti-HMGCR myopathy
Cardiorenal Syndrome (CRS) Types
 • Type 1 - Acute CRS: Alteration of renal perfusion is the
Cardiorenal Syndrome ... Hypertension, CKD induced myopathy ... shifts may be in cause ... #Cardiorenal #Syndrome ... #CRS #Types #cardiology
Acute Coronary Syndrome - Diagnostic Likelihood Ratios for Symptoms and Physical Examination. 

Source:  Does This
Acute Coronary Syndrome ... - Diagnostic Likelihood ... #EBM #Diagnosis ... #Cardiology #ACS ... AcuteCoronarySyndrome #Symptoms #Signs
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... MSAs #clinical #diagnosis ... #rheumatology #table
Important Causes of Diplopia 
TIER 1-CRITICAL
Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn
TIER 2-EMERGENT:
Vertebral dissection, Myasthenia gravis,
Important Causes ... , Orbital apex syndrome ... Miller-Fisher syndrome ... sclerosis, Thyroid myopathy ... #differential #diagnosis
Reflex Testing - Causes of Hyporeflexia and Hyperreflexia
Focal Hyporeflexia: 
 • Radiculopathy, Mononeuropathy, Polyneuropathy, Acute stroke,
Reflex Testing - Causes ... Guillain-Barré syndrome ... Hyperthyroidism, Serotonin syndrome ... #differential #diagnosis ... #table #neurology
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... proximal weakness Myopathy ... mediated necrotizing myopathy ... #Differential #Diagnosis
Abdominal Distention - Differential Diagnostic Algorithm
Ascites
Bowel Dilatation
Other Causes
Mechanical Obstruction
 • Adhesions 60%
 • Volvulus 3%
 •
- Differential Diagnostic ... Dilatation Other Causes ... Intestinal Ogilvie's Syndrome ... • Ischemic Myopathic ... Scleroderma • Familial Myopathy
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
- Differential Diagnosis ... I am weak": • Myopathy ... Polyneuropathy, ALS ... #Differential #Diagnosis ... #causes #neurology