22 results
differential neurology rheumatology management rhabdomyolysis treatment weakness algorithm clinical inflammatory myopathies nephrology symptoms angina antibodies bradi bradycardia cardiorenal chf ck
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Autoimmune Myositis ... Necrotizing myopathy ... anti-synthetase syndrome ... and anti-HMGCR myopathy ... #Myositis #diagnosis
Idiopathic Inflammatory Myopathies (IIM's) RASH + MUSCLE WEAKNESS → Consider idiopathic inflammatory myopathies (IIM's) • Overlap Myositis
Any inflammatory myopathy ... antisynthetase syndrome ... Inflammatory myopathy ... #IIMs #diagnosis ... #dermatology #Myopathy
Creatine Kinase - Causes of Elevated CK Levels Acute CK Elevation (Pain > Weakness): • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... - Autoimmune ... Inclusion body myositis
Myositis Specific Antibodies (MSAs) Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ Immune Mediated
Myositis Specific ... Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... MSAs #clinical #diagnosis ... #rheumatology #table
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
- Differential Diagnosis ... Lack of UMN/LMN signs ... proximal weakness Myopathy ... mediated necrotizing myopathy ... • Autoimmune:
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Causes of Neuromuscular ... Tetanus, Transverse Myelitis ... Motor Nerves: ALS ... Mitochondrial myopathy ... #differential #diagnosis
Important Causes of Diplopia TIER 1-CRITICAL Basilar artery thrombosis, Botulism, Basilar meningitis, Aneurysmn TIER 2-EMERGENT: Vertebral dissection, Myasthenia gravis,
Important Causes ... , Orbital apex syndrome ... sclerosis, Thyroid myopathy ... neuropathy, Orbital myositis ... #differential #diagnosis
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Normal CK - Myositis ... femoral heads • Myopathy ... (Also caused by ... pathophysiology #signs ... #symptoms #diagnosis
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
- Differential Diagnosis ... I am weak": • Myopathy ... Polyneuropathy, ALS ... Inflammatory/Rheum: Myositis ... #causes #neurology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... heliotrope, shawl sign ... exclusion Necrotizing Autoimmune ... Myositis • Onset ... #rheumatology #table
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