20 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Toxicity - Summary Clinical ... proximal myalgia and weakness ... symmetric muscle weakness ... IU/I • SAMS clinical ... #diagnosis #management
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
(COVID19, CMV/EBV ... Illness Myopathy ... - Inflammatory myopathy ... polymyositis, necrotizing myopathy ... #differential #diagnosis
Acute Coronary Syndrome - Diagnostic Likelihood Ratios for Symptoms and Physical Examination. 

Source:  Does This
Acute Coronary Syndrome ... : The Rational Clinical ... #EBM #Diagnosis ... #Cardiology #ACS ... Atypical #ChestPain #Cardiac
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Diagnosis Framework ... Non-neuromuscular disorder (Cardiac ... Myopathy: ... mediated necrotizing myopathy ... #Differential #Diagnosis
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Neuromuscular Weakness ... Motor Nerves: ALS ... heavy metals), Critical ... Mitochondrial myopathy ... #differential #diagnosis
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Generalized Weakness ... Infectious: Influenza, EBV ... I am weak": • Myopathy ... Rhabdomyolysis, Critical ... Polyneuropathy, ALS
Acute Coronary Syndrome - Diagnostic Likelihood Ratios for Symptoms and Physical Examination. Source: Fanaroff AC, Rymer
Acute Coronary Syndrome ... : The Rational Clinical ... #EBM #Diagnosis ... #Cardiology #ACS ... Atypical #ChestPain #Cardiac
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... Antibodies #MSAs #clinical ... #diagnosis #rheumatology ... #table
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
- Differential Diagnosis ... • Cardio-pulmonary ... Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... #Differential #Diagnosis
ISCHEMIA Trial - Management Algorithm for patients with Stable Angina

Stress Test -> ? +moderate or severe
LMCA lesion -> Cardiac ... acute coronary syndrome ... (ACS) evaluation ... Angina #ChestPain #Diagnosis ... #EBM #Trial