52 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Myositis and Myopathies ... #ESR #CK #Differential ... #Inflammatory #myopathies ... #Drug-induced myopathies
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Myositis and Myopathies ... weakness • Elevated CK ... rash • Elevated CK ... mildly elevated CK ... BostonChiefs #Myositis #Myopathies
Inflammatory Myopathies
Dermatomyositis
 • Onset: Subacute
 • Pattern: Proximal
 • CK: Up to 50X ULN
 • Autoantibodies:
Inflammatory Myopathies ... : Proximal • CK ... : Proximal • CK ... : Proximal • CK ... #Inflammatory #Myopathies
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Causes of Elevated CK ... Levels Acute CK ... - Metabolic Myopathies ... ASYMPTOMATIC: Macro CK ... Kinase #Elevated #CK
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Inflammatory Myopathies ... , drug-induced myopathies ... Tests: • Measure CK ... (symmetric) • CK ... muscle weakness • CK
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
→ Inflammatory myopathies ... Diagnosis: • CK
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... #Inflammatory #Myopathies
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... CK may increase ... creatine kinase (CK ... CK functions as ... CK has a half-life
RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... and cefdinir #CK
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK