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diagnosis differential erythematosus hematology lupus management sle disease monoclonal workup abnormal anca antineutrophil antinxp2 antinxp2dm aptt arthritis associations autoantibodies causes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... ) • Systemic lupus ... #Antinuclear #Antibody ... #rheumatology #
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... (anti-nuclear antibody ... others (RNP, aPL antibodies ... Antiphospholipid Antibody ... • Scleroderma (Systemic
I’M DAMN SHARP - Lupus Diagnosis Mnemonic I Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid) M Malar Rash D
Discoid Rash A Antinuclear ... Antibody (ANA) ... Arthritis R Renal ... IMDAMNSHARP #sle #systemic ... erythematosus #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers ... @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
Classification Criteria for Systemic ... hemolysis • Renal ... low C4, Low C3 and ... Highly specific antibodies ... Erythematosus #diagnosis #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
female, asian • Systemic ... pancreas, biliary, renal ... autoantibodies (antinuclear ... antibodies, rheumatoid ... workup #treatment #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... affected joint • Systemic ... erythematosus (SLE) - Antinuclear ... antibody (ANA) ... antibodies, which
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
antiphospholipid antibodies ... FVIII antibody ... antiphospholipid antibodies ... associated with systemic ... #differential #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
(HCV) • CLL & MBL ... clubbing Clarkson/Systemic ... neuropathy) • Systemic ... , retinal, DVT, ... Paraproteinemias #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... ab • RF • Antinuclear ... antibodies ≥ 1: ... Central nervous system ... Sjogrens #Syndrome #Rheumatology
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