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diagnosis lupus disease erythematosus syndrome systemic anca antibody antineutrophil antinxp2 antinxp2dm behcet dermatology dermatomyositis diseases hcq hydroxychloroquine igg4 levels measurement
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... scleroderma) - Anti-Scl ... #Antinuclear #Antibody ... #rheumatology #
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Erythematosus - Summary Antinuclear ... (ANA) - 95% - Initial ... severe disease & renal ... Summary #diagnosis #rheumatology ... #management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... and probably < ... Special cases (e.g. renal ... #rheumatology # ... levels #lupus #management
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pancreas, biliary, renal ... autoantibodies (antinuclear ... antibodies, rheumatoid ... Disease #diagnosis #management ... workup #treatment #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... La, anti-Jo-1, SCL ... -70, RNP antibodies ... anticardiolipin antibodies
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
disease (panuveitis, retinal ... Oral aphthae : SLE ... • Arthritis: SLE ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... ab • RF • Antinuclear ... antibodies ≥ 1: ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... dorsal part of the MCP ... • Clear cell renal ... Dermatomyositis #diagnosis #management ... #rheumatology #
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
cases such as: • SLE ... Heart failure • Renal ... Anti-Matrilin-1 Ab ○ Antibodies ... Polychondritis #rheumatology ... #diagnosis #management
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