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management rheumatology lupus neurology disease druginduced syndrome thrombocytopenia adultonset behcet causes cerebritis cns coagulation comparison dic differential dil disseminated erythematosus
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
♀, ↑Age, ESRD Pathophysiology ... titer (ELISA) - ↑Sens ... A/C if clinical ... #Management #Treatment ... #Hematology #HemeOnc
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Disease, PRES Pathophysiology ... permeability Diagnosis ... Erythematosus #SLE
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... splenomegaly • Hepatic ... • Ocular: uveitis ... #management #treatment ... #rheumatology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
rheumatoid arthritis, SLE ... Ocular- 50%: Ptosis ... weakness, arms > legs ... myasthenia Diagnosis ... Bedside: ice pack
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... - Cytopenia - Less ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... +++ (Plt, Hb), Hepatic ... Autoimmune diseases: SLE
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... Behcet syndrome (Clinical ... Oral aphthae : SLE ... • Arthritis: SLE ... Arthritis, AS Treatment
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Transverse Myelitis - Clinical ... Evaluate for NMO, SLE ... Disorders: - SLE ... Transverse Myelitis Treatment
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... gland) biopsy • Ocular ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... Adenocarcinoma Treatment
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