32 results
Disseminated Cutaneous Blastomycosis- A fungal culture of skin tissue was negative; however, a skin biopsy showed
Disseminated Cutaneous Blastomycosis ... staining confirmed a diagnosis ... #clinical #photo ... #derm #NEJM #cutaneous ... #blastomycosis
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
& inflammatory cells ... ) Clinical: ... • Neurologic: Bell's ... #Sarcoidosis #Diagnosis ... #Symptoms #Signs
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Pathogenesis and clinical ... mutated in all cells ... Retinoblastoma Signs ... ophthalmology #diagnosis ... #signs #symptoms
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
Pathogenesis and clinical ... Signs of immunodeficiency ... maturation of B cells ... from precursor cells ... humoral immunity Signs
Skin Mottling - Skin mottling, a common clinical sign in patients in shock, is a violaceous
mottling, a common clinical ... sign in patients ... treatment (Panel B) #Clinical ... #Derm #PCC #Mottling ... Hypoperfusion #Shock #NEJM
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... >10 mmHg - clinically ... significant portal HTN Signs ... obstruction) • Lack ... of signs of increased
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
- Microglial cells ... of UMN and LMN signs ... of UMN and LMN signs ... both UMN and LMN signs ... EMG: LMN Signs in
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma Diagnosis ... Management Summary Clinical ... Signs: • hyperCalcemia ... pathologic fx) Diagnosis ... marrow plasma cells
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Pathogenesis and Clinical ... B and CD-4+ T cells ... pathophysiology #diagnosis ... #signs #symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Pathogenesis and Clinical ... various inflammatory cells ... histopathologic term ... Pathophysiology #Diagnosis ... #Signs #Symptoms