13 results
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
go on to block blood ... exclusively affects black ... The underlying pathophysiology ... #Features #Signs ... #Symptoms
Skin Mottling - Skin mottling, a common clinical sign in patients in shock, is a violaceous
common clinical sign ... is due to skin hypoperfusion ... B) #Clinical #Derm ... PCC #Mottling #Hypoperfusion ... #Shock #NEJM
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
-> GAS antigen cross-reacts ... B and CD-4+ T cells ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Clinical Manifestations of Sickle Cell Disease

Anaemia
Infection
Painful crises
Priapism
Splenomegaly
Long Term Problems - Short stature and delayed puberty, Stroke
Infection Painful crises ... Splenomegaly Long Term ... SickleCell #Disease #Signs ... #Symptoms #Diagnosis
X-Linked Agammaglobulinemia: Pathogenesis and clinical findings
The epidemiology of this disease is 1/340,000 births and roughly double
remainder likely arises ... Signs of immunodeficiency ... humoral immunity Signs ... /Symptoms/Findings ... Agammaglobulinemia #XLinked #pathophysiology
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
various inflammatory cells ... histopathologic term ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Avascular Necrosis: Pathogenesis and Clinical Findings
 • Physical Trauma (esp. to the scaphoid bone with damage
disease (sickle crisis ... hypolucency "Crescent sign ... AvascularNecrosis #pathophysiology ... #diagnosis #signs ... #symptoms
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
small joints (wrists ... • Plasma cells ... Extra-articular signs ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Scoliosis: Pathogenesis and clinical findings (Cobb Angle > 10 Degrees)

 • Incr Axial rotation of thoracic
-> The pelvis is ... Asymmetrical Iliac Crests ... #Scoliosis #pathophysiology ... msk #diagnosis #signs ... #symptoms
Non-Infective Endocarditis (NBTE / Marantic Endocarditis)
Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
heart valves • Lack ... Inflammatory cells ... pathognomonic signs ... /symptoms or echo ... Marantic #diagnosis #pathophysiology