37 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
Pathogenesis and Clinical ... chromosome 21) Signs ... Inattention and lack ... AlzheimersDisease #Dementia #pathophysiology ... geriatrics #diagnosis #signs
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
Pathogenesis and clinical ... mutated in all cells ... Retinoblastoma Signs ... Retinoblastoma #pathophysiology ... ophthalmology #diagnosis #signs
Skin Mottling - Skin mottling, a common clinical sign in patients in shock, is a violaceous
mottling, a common clinical ... sign in patients ... treatment (Panel B) #Clinical ... #Derm #PCC #Mottling ... Hypoperfusion #Shock #NEJM
Meralgia paresthetica: Pathogenesis and Clinical Findings
Compression/injury of Lateral Femoral Cutaneous Nerve (LFCN) -> Meralgia paresthetica
 •
Pathogenesis and Clinical ... absent: lower back ... MeralgiaParesthetica #MSK #pathophysiology ... differential #diagnosis #signs ... #symptoms
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
go on to block blood ... exclusively affects black ... The underlying pathophysiology ... Crisis #Features #Signs ... #Symptoms
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
the long bone or pelvis ... Pathophysiology ... FES is a clinical ... Syndrome #Diagnosis #Signs ... #Symptoms
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
extrapulmonary cases Clinical ... Signs/Symptoms: ... Insidious, progressive back ... years - May have signs ... decreased reflexes Pathophysiology
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
Osteoarthritis (OA): Clinical ... Bouchard's nodes) • Lack ... Osteoarthritis #OA #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Pathogenesis and Clinical ... B and CD-4+ T cells ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Evolution of Purpura Fulminans - On physical examination, he had small purpura on his legs (Panel
(Panel B), and signs ... #Clinical #Derm ... Meningococcemia #NEJM