13 results
Alzheimer’s Disease: Pathogenesis and Clinical Findings
Risk factor for Late Onset Alzheimer's (99% of cases):
 - Increasing
chromosome 21) Signs ... / Symptoms / Complications ... Inattention and lack ... AlzheimersDisease #Dementia #pathophysiology ... geriatrics #diagnosis #signs
Acute Otitis Media: Complications
Infection and inflammation of the middle ear
 - Prolonged obstruction of e. tube
to mastoid air cells ... becomes more severe Signs ... /Symptoms/Complications ... #pathophysiology ... #symptoms #signs
Retinoblastoma: Pathogenesis and clinical findings
 • Sporadic mutation -> One allele of RB1 tumor suppressor gene
mutated in all cells ... Retinoblastoma Signs ... / Symptoms / Complications ... Retinoblastoma #pathophysiology ... ophthalmology #diagnosis #signs
Osteoarthritis (OA): Clinical findings
 • Stimulation of joint nociceptors in subchondral bone -> Pain with loading
Bouchard's nodes) • Lack ... Osteoarthritis #OA #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
B and CD-4+ T cells ... RheumaticFever #pathophysiology ... #diagnosis #signs ... #symptoms #complications
Features of a Sickle Cell Crisis 
Sickle-cell disease - an autosomal recessive blood disorder.
Characterized by red
go on to block blood ... exclusively affects black ... The underlying pathophysiology ... Crisis #Features #Signs ... #Symptoms
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
• Langerhan cells ... removal of these cells ... Manifestations #pathophysiology ... #diagnosis #signs ... #symptoms #complications
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
various inflammatory cells ... histopathologic term ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
diffusion of K+ out of cells ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology
Non-Infective Endocarditis (NBTE / Marantic Endocarditis)
Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
heart valves • Lack ... Inflammatory cells ... pathognomonic signs ... /symptoms or echo ... Marantic #diagnosis #pathophysiology