8 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... - Differential Diagnosis ... Cold AIHA • PCH ... • PNH ... #Differential #Diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... Diagnosis: • hemolytic ... for anti-C3d and negative ... - Mycoplasma, EBV ... Hemoglobinuria (PCH
Causes of Acute Pharyngitis
• 200 visits per year per 1000 people
   - i.e. 400
visits/year for a PCP ... - 11 million diagnoses ... (herpangina), EBV ... • Group A beta-hemolytic ... #differential #diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Drug-associated, PCH ... Liver Disease, PNH ... #Differential #Diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... HBV, HCV, HEV, EBV ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis ... #differential #diagnosis
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
disease, C3GN, CFHR5 neph ... immune deposits on EM ... , negative IF ... MPGN #nephrology #diagnosis
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
- Differential Diagnosis ... Encephalitis: MCC ... virus • CMV • EBV ... in 70%-85% • Negative ... Monocytogenes or gram negative
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic ... #Differential #Diagnosis