11 results
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
structure of a normal ... mediated by the proteins ... of the shaded proteins ... Pathophysiology #Honc ... HereditarySpherocytosis #NEJM
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH ... Liver Disease, PNH ... Blood Smear ↑ abnormal ... Differential #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... • PNH ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Retiform purpura - Protein ... deficiencies - PNH ... Decreased Support Of Dermal ... Differential #Diagnosis #hematology ... #rheumatology #
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
virus • CMV • EBV ... mildly elevated protein ... Mildly decreased/Normal ... glucose level, • Normal ... <40 mg/dL • Normal
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
(G20210A) - Protein ... deficiency - Protein ... • Drugs: - Oral ... - COVID-19 - PNH ... pathophysiology #hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... , PSC, IgG4, HLH ... - If both are normal ... function may be abnormal ... diagnosis #algorithm #hepatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
acute HIV, HBV, EBV ... gastric tumors • Hematology ... chain assay • An abnormal ... light chain • Normal ... differential #diagnosis #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Feature A Monoclonal Protein ... Cryoglobulinemic, Hypo/normo-complementemic ... WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Malignancy (e.g. hematologic ... pancreatitis, protein-losing ... Antiribosomal P, APLA, PAC ... vein thrombosis Hematologic