7 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... Drug-induced AIHA - Abnormal ... • Hereditary spherocytosis ... Cold AIHA • PCH ... • PNH
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Hemolysis in Hereditary ... Spherocytosis. ... structure of a normal ... Pathophysiology #Honc ... #NEJM
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Bacterial • Viral (EBV ... Hepatic, Portal, ... Serum Sickness Hemolytic ... • Congenital Spherocytosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH ... Liver Disease, PNH ... Blood Smear ↑ abnormal ... Urobilinogen #Hemolysis
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
upon damage • Normal ... bloodstream Hemolysis ... : • Hemolytic ... Anemias: - Spherocytosis ... anemia, PNH, immune
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... - If both are normal ... Gilbert's syndrome • Hemolysis ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Cryoglobulinemic, Hypo/normo-complementemic ... WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic