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algorithm hematology hepatology injury liver causes hemolysis acute agglutinin anemia disease extravascular gap globulin hemolytic hepatocellular intravascular lfts management myopathy
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... C, A, E, B, D, EBV ... Other: NAFLD, Autoimmune ... #Diagnosis #Causes
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Membrane): - Autoimmune ... : Warm AIHA, Cold ... Drug-associated, PCH ... Liver Disease, PNH ... Laboratory Tests
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... - Mycoplasma, EBV ... CLL (older) • Autoimmune ... younger pts) Differential ... test #cold #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... Warm AIHA • Cold ... AIHA • Alloimmune ... AIHA • PCH ... • PNH
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver test ... Infections: Hepatitis ... A/B/C/D/E, EBV, ... Other: NAFLD, Autoimmune ... Transaminitis #LFTs #hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... HBV, HCV, HEV, EBV ... : Autoimmune hepatitis ... extrahepatic source - Tests
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Diagnosis Framework ... of the spinal cord ... necrotizing myopathy • Autoimmune ... ) ANCA titers, hepatitis
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
OnePager Summary Autoimmune ... coagulopathy) • CBC w differential ... ) Other tests: ... of PRS: Biopsy (gold ... Renal #Syndromes #differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... Gap #ProteinGap #differential ... #diagnosis #hematology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential ... Tests: • Measure ... • ANA < 20 % IBM ... , autoimmune hepatitis ... #rheumatology #differential
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