11 results
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Liver Injury - Differential ... C, A, E, B, D, EBV ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Liver #Injury #Differential
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... HBV, HCV, HEV, EBV ... extrahepatic source - Tests ... Chronic viral hepatitis ... #differential #
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Liver Injury - Differential ... Injury → liver test ... • Infections: Hepatitis ... A/B/C/D/E, EBV, ... Transaminitis #LFTs #hepatitis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH ... Liver Disease, PNH ... Laboratory Tests ... #Hemolysis #Differential
Cytomegalovirus (CMV) in HIV-AIDS Patients
Cytomegalovirus (CMV): double-stranded DNA virus, herpesvirus family.
CMV infection: virus isolation or detection
: Quantitative PCR ... pp65 antigenemia test ... AIDS) • Liver: Hepatitis ... AIDS #diagnosis #differential
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Mycoplasma, EBV ... younger pts) Differential ... Hemoglobinuria (PCH ... • Diagnostic Test ... Donath-Landsteiner test
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework

Viral Encephalitis:
MCC: Enteroviruses (e.g., coxsackievirus
Bacterial Meningitis - Differential ... virus • CMV • EBV ... Arboviruses: - West ... Good indicator to differentiate ... CNS #Infections #differential
1,3-Beta-D-Glucan and Galactomannan Testing Sensitivity Specificity and False Positives
1,3-Beta-D-Glucan
 • Cell wall component of many fungi
Other +s: PCP, Histo ... IA PPV NPV ... the use of this test ... in BAL does not differentiate
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... glomerulonephritis) • Anti-GBM ... lesions-interstitial keratitis ... ear disease Differential ... retinopathy Lab Tests
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
acute HIV, HBV, EBV ... , VZV, hepatitis ... ETOH, autoimmune hepatitis ... , PBC, PSC, Viral ... Gap #ProteinGap #differential