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diagnosis differential algorithm hepatology injury liver rheumatology acute agglutinin anemia antibodies associations autoantibodies autoimmune causes classification cold disease diseases gap
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... C, A, E, B, D, EBV ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Acute #algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
HBV, HCV, HEV, EBV ... extrahepatic source - Tests ... Chronic viral hepatitis ... liver #injury #hepatitis ... diagnosis #algorithm #hepatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
SLE, autoimmune hepatitis ... ) - Autoimmune hepatitis ... biliary cirrhosis (PBC ... Celiac disease Anti-GBM ... diagnosis #table #rheumatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury → liver test ... • Infections: Hepatitis ... A/B/C/D/E, EBV, ... Differential #Diagnosis #hepatology ... Transaminitis #LFTs #hepatitis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH ... Liver Disease, PNH ... Laboratory Tests ... Differential #Diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Mycoplasma, EBV ... Hemoglobinuria (PCH ... • Diagnostic Test ... Donath-Landsteiner test ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
acute HIV, HBV, EBV ... , VZV, hepatitis ... , PBC, PSC, Viral ... gastric tumors • Hematology ... differential #diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
glomerulonephritis) • Anti-GBM ... lesions-interstitial keratitis ... retinopathy Lab Tests ... differential #diagnosis #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Diagnostic Tests ... • ANA < 20 % IBM ... Other Diseases: • PBC ... , autoimmune hepatitis ... Myositis #Myopathy #rheumatology
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