15 results
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Prothrombin Time (PT ... inhibitor • Liver ... elevated in: • Heparin ... elevated in: • DIC ... Thromboplastin #laboratory #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... Bleeding (64%) • Renal ... Fibrinogen: ↓ • PT ... • Severe Liver ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... • Reduced liver ... intravascularcoagulation (DIC ... #differential #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... deficiency • Liver ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... intravascular coagulation (DIC ... #differential #hematology
Portal venous gas on hepatic ultrasound: A concerning finding in the critically ill patient that should
ultrasound: A concerning ... of air in the hepatic ... variety of other causes ... #hepatology #liver ... #pocus #clinical
Hepatic Metastases on POCUS 
Patient with history of colon cancer presents with right flank pain. Focused
on POCUS Patient ... with history of colon ... Focused renal u/ ... Note hepatic masses ... #ultrasound #metastatic
Hepatic Metastases on POCUS 
Patient with history of colon cancer presents with right flank pain. Focused
on POCUS Patient ... with history of colon ... Focused renal u/ ... Note hepatic masses ... #ultrasound #metastatic
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
Acquired: • Heparin ... Warfarin • Acute DIC ... discern these causes ... disease • Acute DIC ... Differential #Diagnosis #Hematology
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
NEJM 1999 - ICU FOCUS ... Blood saves lives ... unnecessary and cause ... critically ill, septic ... Transfusion #Thresholds #Hematology