61 results
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
and sources of infection ... • Native and ... • Soft tissue infections ... #Sources #Causes ... #Differential #Microbiology
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... culture negative ... infective endocarditis ... #Endocarditis # ... InfectiousDiseases #Microbiology
Endocarditis Algorithm - Infective vs Noninfective Causes
Noninfective:
 • Malignancy
 • Autoimmune disease
 • Systemic infection
Native Valve
Endocarditis Algorithm ... vs Noninfective Causes ... disease • Systemic infection ... amzn.to/2LmUODZ #Endocarditis ... #Noninfective #Causes
Blood culture contaminants
Grouped by gram negative vs gram positive vs other as well as never/maybe/probably
Some additional
Blood culture contaminants ... Grouped by gram negative ... febrilepodcast] #ID #Infectious ... Diseases #Infections ... #Microbiology #
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
serology: Serial negative ... Frequent false-negative ... in up to 30% of cases ... large infarct - Infectious ... #comparison #infective
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... after 3 separate blood ... but important causes ... #Infective #Endocarditis
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Reactive: • Anemia/blood ... deficiency) • Infection ... Sepsis • Non-infectious ... Differential #Diagnosis #causes ... #Platelets #hematology
My Patient with Infective Endocarditis (IE) Has Negative Blood Cultures
 - Did they receive antibiotics prior
with Infective Endocarditis ... (IE) Has Negative ... Blood Cultures ... therapy - Number one cause ... #Infective #Endocarditis
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Streptocccus Pneumoniae Microbiology ... Alpha-hemolytic, Catalase Negative ... • Most common cause ... media • Important cause ... peritonitis, and endocarditis
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS) Microbiology ... : Blood cultures ... • Coagulase-negative ... • Blood cultures ... Treat underlying cause