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HACEK is the acronym commonly used to describe and help doctors to remember a group of
fastidious Gram-negative ... which can also cause ... endocarditis is caused ... endocarditis is caused ... #Diagnosis #InfectiousDiseases
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
Causes of blood ... culture negative ... febrilepodcast] #BCNIE #Causes ... #culture #negative ... #Endocarditis #InfectiousDiseases
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Staphylococci (skin), Gram-negative ... Staphylococci (skin), Gram-negative ... differential #diagnosis #causes ... #infectiousdiseases
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture ... Negative Abscess ... antibiotics as a cause ... of a negative culture ... Differential #Diagnosis #InfectiousDiseases
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... cultures remain negative ... but important causes ... #BloodCulture #Negative ... differential #workup #infectiousdiseases
Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
epidermidis - Gram-negative ... ) - Culture negative ... Enterococci - Gram-negative ... streptococci - Culture negative ... #Differential #InfectiousDiseases
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
aureus, Coagulase-negative ... staphylococci Culture Negative ... Septic emboli cause ... Treat underlying cause ... Diagnosis #cardiology #infectiousdiseases
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Drug fever #relative ... #bradycardia #Causes ... differential #diagnosis #infectiousdiseases
Endocarditis Algorithm - Infective vs Noninfective Causes Noninfective: • Malignancy • Autoimmune disease • Systemic infection Native Valve
vs Noninfective Causes ... HACEK • Culture-negative ... epidermidis • Gram-negative ... Enterococcus • Gram-negative ... #Noninfective #Causes
Important Biostatistics and Epidemiology Equations Sensitivity = TP / (TP + FN) = true positives / disease
FP + TN) = true negatives ... all positives Negative ... FN + TN) = true negatives ... / all negatives ... Specificity) Negative
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