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Microorganisms Responsible for Infective Endocarditis Native valves: - Streptococcus viridans - Enterococci - Other streptococci
epidermidis - Gram-negative ... ) - Culture negative ... Enterococci - Gram-negative ... Pathogens #Diagnosis #Differential ... #InfectiousDiseases
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
blood culture negative ... BCNIE #Causes #differential ... causes #culture #negative ... #Endocarditis #InfectiousDiseases
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Staphylococci (skin), Gram-negative ... Staphylococci (skin), Gram-negative ... Infections #Timeline #differential ... diagnosis #causes #infectiousdiseases
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture Negative ... Abscess - Differential ... as a cause of a negative ... #Abscess #Differential ... #Diagnosis #InfectiousDiseases
Blood Culture-Negative Infective Endocarditis (BCNIE) Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... cultures remain negative ... #BloodCulture #Negative ... Endocarditis #diagnosis #differential ... #workup #infectiousdiseases
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
- Overview and Differential ... aureus, Coagulase-negative ... staphylococci Culture Negative ... #Endocarditis #Differential ... Diagnosis #cardiology #infectiousdiseases
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Drug fever #relative ... bradycardia #Causes #differential ... #diagnosis #infectiousdiseases
Endocarditis Algorithm - Infective vs Noninfective Causes Noninfective: • Malignancy • Autoimmune disease • Systemic infection Native Valve
Systemic infection Native ... HACEK • Culture-negative ... epidermidis • Gram-negative ... Enterococcus • Gram-negative ... Noninfective #Causes #Differential
Important Biostatistics and Epidemiology Equations Sensitivity = TP / (TP + FN) = true positives / disease
FP + TN) = true negatives ... all positives Negative ... FN + TN) = true negatives ... / all negatives ... Specificity) Negative
Table 3. Suggested Empiric Treatment Options for Clinically Suspected Ventilator-Associated Pneumonia in Units Where Empiric Methicillin-Resistant
Antipseudomonal/Gram-Negative ... Appropriate #Management #InfectiousDiseases
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