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Microorganisms Responsible for Infective Endocarditis

Native valves:
 - Streptococcus viridans 
 - Enterococci 
 - Other streptococci
epidermidis - Gram-negative ... ) - Culture negative ... Enterococci - Gram-negative ... streptococci - Culture negative ... #Differential #InfectiousDiseases
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Anemia (AIHA) Pathophysiology ... C3 positive or negative ... mediated - DAT: IgG negative ... Hemolytic #Anemia #Pathophysiology
Important Biostatistics and Epidemiology Equations

Sensitivity = TP / (TP + FN) = true positives / disease
FP + TN) = true negatives ... all positives Negative ... FN + TN) = true negatives ... / all negatives ... Specificity) Negative
Table 3. Suggested Empiric Treatment Options for Clinically Suspected Ventilator-Associated Pneumonia in Units Where Empiric Methicillin-Resistant
Antipseudomonal/Gram-Negative ... Appropriate #Management #InfectiousDiseases
Transplant Infections Timeline
Pre-transplant:
 • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut)
 • Viruses: HSV (reactivation)
Engraftment:
Staphylococci (skin), Gram-negative ... Staphylococci (skin), Gram-negative ... diagnosis #causes #infectiousdiseases
Endocarditis Algorithm - Infective vs Noninfective Causes
Noninfective:
 • Malignancy
 • Autoimmune disease
 • Systemic infection
Native Valve
Systemic infection Native ... Staphylococcus lugdunensis Native ... HACEK • Culture-negative ... epidermidis • Gram-negative ... Enterococcus • Gram-negative
The principal endocrine 'axes' and glands. Parathyroid glands, adrenal zona glomerulosa and endocrine pancreas are not
Italics show negative ... Endocrinology #Pathophysiology
Causes of Relative Bradycardia - Note the propensity for intracellular organisms.
Infectious: 
Legionella, Psittacosis, Q fever, Typhoid
Causes of Relative ... Drug fever #relative ... differential #diagnosis #infectiousdiseases
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
blood culture negative ... causes #culture #negative ... #Endocarditis #InfectiousDiseases
HACEK is the acronym commonly used to describe and help doctors to remember a group of
fastidious Gram-negative ... #Diagnosis #InfectiousDiseases