58 results
Tularemia - Diagnosis and Management Summary
Francisella tularensis - Aerobic fastidious gram-negative Coccobacillus - Zoonotic Infection
 •
Diagnosis and Management ... fastidious gram-negative ... Coccobacillus - Zoonotic Infection ... : 1) Ciprofloxacin ... #treatment #infectiousdiseases
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Affects 1:25,000 ... and 1:50,000 patients ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Into Two Types: 1. ... Malignancy • Infections ... levels >1g/L • Negative ... cryoglobulins • Negative ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Antibodies: 1. ... - Due to Viral infection ... Polyclonal - Viral Infection ... for anti-C3d and negative ... hemolytic #anemia #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... • Autoimmune diseases ... Adult-onset Still disease ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework

NCPE Pathophysiology:
Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
Framework NCPE Pathophysiology ... Causes include: 1. ... acute cardiac disease ... edema • Bowel infarction ... differential #diagnosis #cardiology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Steroids - 1-2 ... esp if severe disease ... Polyclonal: - Infection ... AIHA #Treatment #management ... #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Overview Normal: < 1% ... • Autoimmune diseases ... likelihood of negative ... neutrophil #WBC #CBC #hematology ... #pathophysiology
Causes of Myocarditis 
1. Infectious Myocarditis
 • Bacterial - Staphylococcus, Streptococcus, Pneumococcus, Meningococcus, Gonococcus, Salmonella, Corynebacterium
Myocarditis 1. ... immunodeficiency virus-1 ... Autoantigens - Infection-negative ... lymphocytic, infection-negative ... differential #diagnosis #cardiology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Diagnosis and Management ... Age 20-40, F:M 9:1 ... pANCA anti-MPO - Negative ... Evolution: Chronic disease ... #Summary #rheumatology