10 results
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
Infective endocarditis ... • Native and ... prosthetic valve endocarditis ... #Infective #Endocarditis ... #Differential #Microbiology
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
blood culture negative ... infective endocarditis ... causes #culture #negative ... #Endocarditis # ... InfectiousDiseases #Microbiology
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Streptocccus Pneumoniae Microbiology ... Alpha-hemolytic, Catalase Negative ... peritonitis, and endocarditis ... Meningitis 10-14 days, Endocarditis ... Pneumoniae #strep #microbiology
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
from Infective Endocarditis ... serology: Serial negative ... Frequent false-negative ... cultures/serology: + (Negative ... #comparison #infective
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Endocarditis Summary ... Hypercoagulable (APLAS) Microbiology ... Prosthetic Valve Endocarditis ... • Coagulase-negative ... #Endocarditis
Capnocytophaga
Pathogen: Capnocytophaga
 • 9 species, C. canimorsus responsible for the majority of infections
 • Gram-negative rod,
infections • Gram-negative ... 13%), Pneumonia, Endocarditis ... fusiform gram-negative ... Capnocytophaga #canimorsus #microbiology
What's the Dx?
• 29-year-old male 
• Transfer community hospital 
• Hypotension
• Renal failure
• Altered mental status.
Using IV heroin • Negative ... vegetation secondary to endocarditis ... #Clinical #POCUS ... PLAX #Infective #Endocarditis
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
• India ink - "Negative ... Fungal #Stains #microbiology ... fungi #fungus #comparison
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Endocarditis - Overview ... Hypercoagulable (APLAS) Microbiology ... aureus, Coagulase-negative ... staphylococci Culture Negative ... #Endocarditis
Pyogenic liver abscess in children
Common bacterial causes in children:
 • S.aureus
 • Strep spp
 • Enteric
• Enteric gram negative ... from contiguous focus ... artery (e.g., endocarditis