10 results
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
Infective endocarditis ... • Native and ... prosthetic valve endocarditis ... #Sources #Causes ... #Differential #Microbiology
Capnocytophaga
Pathogen: Capnocytophaga
 • 9 species, C. canimorsus responsible for the majority of infections
 • Gram-negative rod,
Capnocytophaga ... infections • Gram-negative ... 13%), Pneumonia, Endocarditis ... fusiform gram-negative ... #canimorsus #microbiology
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... infective endocarditis ... #culture #negative ... #Endocarditis # ... InfectiousDiseases #Microbiology
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Streptocccus Pneumoniae Microbiology ... Alpha-hemolytic, Catalase Negative ... • Most common cause ... media • Important cause ... peritonitis, and endocarditis
Capnocytophaga Canimorsus Skin Rash

40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
dogs & latter can cause ... fastidious gram-negative ... bacillus cause ... to meningitis, endocarditis ... Myocarditis & culture-negative
Capnocytophaga spp on Culture and Blood Smear
Associated w/ dog/human oral flora, can cause bacteremia in immunocompromised
Capnocytophaga spp ... oral flora, can cause ... anaerobe; narrow Gram negative ... richdavisphd #Capnocytophaga ... clinical #microscopy #microbiology
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
serology: Serial negative ... Frequent false-negative ... cultures/serology: + (Negative ... in up to 30% of cases ... #comparison #infective
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS) Microbiology ... positive in 90% of IE cases ... • Coagulase-negative ... Septic Emboli Cause ... Treat underlying cause
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Hypercoagulable (APLAS) Microbiology ... aureus, Coagulase-negative ... staphylococci Culture Negative ... Septic emboli cause ... Treat underlying cause
Pyogenic liver abscess in children
Common bacterial causes in children:
 • S.aureus
 • Strep spp
 • Enteric
Common bacterial causes ... • Enteric gram negative ... from contiguous focus ... artery (e.g., endocarditis