23 results
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
negative infective ... endocarditis Bartonella ... #negative #Endocarditis ... InfectiousDiseases #Microbiology ... #CNIE #BCNIE #cardiology
Blood culture contaminants
Grouped by gram negative vs gram positive vs other as well as never/maybe/probably
Some additional
Blood culture contaminants ... Grouped by gram negative ... #Infections #Microbiology ... #Micro #Differential
Capnocytophaga
Pathogen: Capnocytophaga
 • 9 species, C. canimorsus responsible for the majority of infections
 • Gram-negative rod,
infections • Gram-negative ... 13%), Pneumonia, Endocarditis ... microorganism (Culture ... fusiform gram-negative ... #canimorsus #microbiology
Duke's Criteria for Infective Endocarditis
Definite IE - Pathologic Criteria:
 • Pathologic lesions - vegetation or intracardiac
for Infective Endocarditis ... demonstrating active endocarditis ... demonstrated by culture ... Immunologic phenomena • Micro ... criteria #Infective #Endocarditis
Capnocytophaga spp on Culture and Blood Smear
Associated w/ dog/human oral flora, can cause bacteremia in immunocompromised
Capnocytophaga spp ... anaerobe; narrow Gram negative ... richdavisphd #Capnocytophaga ... #Smear #clinical ... #microscopy #microbiology
Capnocytophaga Canimorsus Skin Rash

40 M presents w/ N, V, severe epigastric pain. SHx: smoker, drinks 18
fastidious gram-negative ... to meningitis, endocarditis ... Myocarditis & culture-negative ... is difficult to culture ... #dermatology #clinical
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Streptocccus Pneumoniae Microbiology ... Alpha-hemolytic, Catalase Negative ... peritonitis, and endocarditis ... sinus • Sputum culture ... Pneumoniae #strep #microbiology
Differentiating NBTE from Infective Endocarditis
No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
high index of clinical ... Hypercoagulable states • Clinical ... serology: Serial negative ... Frequent false-negative ... /serology: + (Negative
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS) Microbiology ... : Blood cultures ... • Coagulase-negative ... • Blood cultures ... diagnosis #management #cardiology
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... Infective Endocarditis ... remain negative ... antimicrobials, clinical ... #Infective #Endocarditis