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diagnosis endocarditis rheumatology activation adult apml differential differentiation disease hemeonc hemophagocytic hepatorenal hlh hrs infectiousdiseases leukostasis lymphohistiocytosis lysis macrophage mas
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE], AOSD ... • Infection (eg ... Histopathologic criteria ... #Diagnosis #Management ... #Hematology #Rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
dysfunction, and negative ... Prednisone 0.5-1mg/kg ... Stills #disease #AOSD ... #diagnosis #rheumatology ... #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Prednisone 5mg/kg ... APML #diagnosis #management ... #hematology #oncology
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
• Coagulase-negative ... -> TEE • Duke Criteria ... ↑ ESR, CRP • EKG ... Endocarditis #diagnosis #management ... #cardiology
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
aureus, Coagulase-negative ... Cholesterol emboli syndrome ... → TEE • Duke Criteria ... ↑ ESR, CRP • EKG ... Differential #Diagnosis #cardiology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... Pathophysiology ... Diagnostic Criteria ... of 8 HLH-2004 criteria ... #Hematology #HemeOnc
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
Hepatorenal Syndrome ... Pathophysiology: ... Diagnosis (Clinical Criteria ... #Hepatorenal #Syndrome ... #Hepatology #Nephrology
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