23 results
Running out of Analgesia and Sedation Medications due to #COVID19?  Anand Swaminathan, MD has put
and Analgesia Alternative ... Medications ... #sedation #sedative ... #analgesia #pharmacology ... #alternatives #
Carbapenems - Antibiotics Class Overview

Imipenem/Cilastin, Meropenem, Ertapenem, Doripenem 

Spectrum: Broadest spectrum antibiotics, cover Gram positive, Gram
Antibiotics Class Overview ... positive, Gram negative ... resistant gram negatives ... #Pharmacology ... Antibiotics #Review #Overview
Aminoglycosides  - Antibiotics Class Overview

Gentamicin, Tobramycin, Amikacin, Streptomycin -30S inhibitor (all IV)
Spectrum: Extremely efficacious vs.
Antibiotics Class Overview ... . aerobic Gram negatives ... infections especially ... #Pharmacology #Antibiotics ... #Review #Overview
Daptomycin  - Antibiotics Class Overview

Mechanism: Lipopeptide antibiotic – forms transmembrane channels and depolarizes cells.
Antibiotics Class Overview ... No gram negative ... skin/soft tissue infections ... cidal nature) #Pharmacology ... Antibiotics #Review #Overview
Tigecycline (IV) - Antibiotics Class Overview

Mechanism: Glycylcycline class - structurally related to Tetracyclines (bacteriostatic).  Only
Antibiotics Class Overview ... and VRE), Gram negatives ... intraabdominal infections ... #Pharmacology #Antibiotics ... #Review #Overview
Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview

Mechanism: Glycopeptide -  inhibits cell wall synthesis
Antibiotics Class Overview ... No gram negative ... gram positive infections ... #Pharmacology #Antibiotics ... #Review #Overview
Sedation and Analgesia Medications - Drug Shortages
Analgesia Options
 - Fentanyl
 - Morphine
 - Hydromorphone
 - Remifenatnil
Sedative
and Analgesia Medications ... Remifenatnil Sedative ... Sedation #Analgesia #Medications ... #Shortages #Pharmacology ... #Alternatives #
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... overlook severe infections ... likelihood of negative ... relative to both ... CBC #hematology #pathophysiology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
duration), Several medications ... tox) Search for alternative ... Hepatocellular: Viral infections ... biopsy if: • Negative
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19

IL-6 activates T cells and macrophages, among other cell types (see
respiratory tract infection ... Neutropenia 2-7% Alternative ... Siltuximab #COVID19 #Pharmacology ... #Management #Medications