19 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... for anti-C3d and negative ... - Mycoplasma, EBV ... hemolytic #anemia #hematology ... #diagnosis
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
- Differential Diagnosis ... hemoglobinuria) • Cold Agglutinin ... AIHA (7-8%) DAT-negative ... #Differential #Diagnosis ... #Table #hematology
Expected DAT Results in Autoimmune Hemolysis
DAT Negative Hemolysis
 • DAT Poly ( - ), IgG (
Hemolysis DAT Negative ... ( +/- ) Cold agglutinin ... Autoimmune #Hemolysis #hematology ... #diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
to Kidney: Anti-GBM ... involvement: Anti-GBM ... Pauci-immune mediated (Negative ... #differential #diagnosis ... #algorithm #rheumatology
Point-of-care Ultrasound for Diagnosis of Abscess in Skin and Soft Tissue Infections

1. POCUS is more accurate
Ultrasound for Diagnosis ... POCUS is more accurate ... POCUS has a negative ... LikelihoodRatios #Accuracy #Diagnosis ... VisualAbstract #EBM
Rheumatoid Arthritis - 2020 ACR-EULAR Classification
≥ 6 of 10 points = definite RA
Joint Involvement:
Arthritis - 2020 ACR-EULAR ... at least 1): Negative ... RF, negative anti ... Rheumatoid #Arthritis #diagnosis ... #rheumatology
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... non-localized EOM ... Her ocular exam ... pack test were negative ... PhysicalExam #clinical #video
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... Coxsackie, CMV, EBV ... • Ocular: uveitis ... Stills #Disease #diagnosis ... management #treatment #rheumatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
pulmonary emboli, and ocular ... Cryofibrinogenemia Diagnosis ... levels >1g/L • Negative ... cryoglobulins • Negative ... #rheumatology #
Empyema Necessitans (EN) on Chest POCUS

Pulmonary teaching case: you are called to the bedside of a
(EN) on Chest POCUS ... chest drain on POCUS ... - What’s the diagnosis ... With inspiration, negative ... Chest #clinical #video